The promise of tissue regeneration and engineering to repair and rebuild damaged tissues and organs has the ability answer many serious needs in healthcare and trauma medicine.

Evolution of Tissue Regeneration

Historically, scientists and clinicians alike have understood the therapeutic promise of cells.  Initially they were removed from harvested living tissue and injected into a patient.  The process of introducing the cells damaged most of them resulting in the injection of a greatly reduced therapeutic capability and a lot of dead or dying tissue. 

The availability of cells improved as scientists learned to grow the cells in a lab on dishes coated with biomolecular structures called extracellular matrices (ECM).   However, as before, when these cells were stripped from the ECM and removed from their dishes, their survival and functional incorporation into the body was poor.

The next phase of innovation involved the use of of porous biomaterial scaffolds to act as an ECM which could act as a carrier to place the cells in vivo.  Used to replace structures like blood vessels and muscle walls this approach shows promise. 

These tissue regeneration technologies and the resulting products do not allow for real integration of the cells into the patient.

The Benefits the Cellarium Regeneration

Cellarium™ and the many benefits of its technology succeed where these approaches have struggled.  Instead of removing cells and manipulating them in the laboratory, the Cellarium provides a local microenvironment that attracts the needed cells (although the device can be loaded if the cells are unavailable in vivo) and manipulates them using the host's body to naturally support the cells. 

Instead of a scaffold where the cells are meant to stay, InCytu's technology manipulates the cells then controls the integration of these now healthy cells back into the host to play a significant therapeutic or regenerative role in the healing process.