Cellarium’s ability to integrate with and enable, repair or replace normal healthy biological processes makes it a transformative force in personalized medicine.
The common to the Cellarium family of products is the ability to:
- Attract a specific cell type into the small porous biomaterial device.
- Temporarily hold the cells
- Educate or proliferate, mature or activate the cells as needed for the selected therapy
- Then controllably return those cells back to the patient where they integrate and play a therapeutic or regenerative role.
These biomaterials can be chosen from a wide variety of candidates:
- Solid scaffolds for manipulating the immune system.
- Flat sheets for repairing non-healing wounds.
- Injectable gels for regenerating lost and damaged soft tissue.
- Sprayable gells for accelerating healing.
- Moldable shapes for space filling and structural repair.
In each case the option exists to use resorbable biomaterials which provide the needed therapy and then dissolve away ... or permanent forms which aid in the structural repair process.
Cellarium intelligent biopolymer devices can be implanted without cells and programmed to attract specific cell populations in the body (e.g. dendritic cells). Or can be loaded with cells in therapeutic applications where sufficient cells do not exist within the patient.
Once the device is placed in vivo and holding cells, clinically acceptable factors within the device, each with pre-programmed release kinetics, safely expand, mature or activate the cells within the device and, in the case of our melanoma vaccine, expose them to tumor lysate that targets the specific cancer cells.
The optimized cells are then directed to leave the Cellarium and integrate into the normal biology... alerting the immune system replacing damaged/diseased tissue or enhance healing. The result is a dramatic functional enhancement of body systems or tissue repair.
Since the Cellarium can be made to resorb, InCytu is capable of deisgning products that go away in a specific time frame thereby allowing finite control of the duration of therapy and associated "dosing".
